Fine particles and lung cancer

Fine particles and lung cancer.

A lmost five decades have elapsed since the effect of the so-called ‘‘urban factor’’ on lung cancer has been suggested. Air pollution has always been an attractive explanation for the 10–40% increase in lung cancer mortality observed in urban versus rural areas, but confounding from smoking and other factors has been a great limitation in interpreting geographical comparisons. Several attempts ...

Impact of fine particles in ambient air on lung cancer

Recently, the International Agency for Research on Cancer (IARC) has classified outdoor air pollution and the particulate matter component of outdoor air pollution as class I carcinogen. Air pollution is consistently associated with lung cancer in epidemiologic and experimental studies. The IARC assessment is specifically designed as hazard identification, and it does not quantify the magnitude...

Mineral particles, mineral fibers, and lung cancer.

The total fibrous and nonfibrous mineral content of the lung has been analyzed in a series of 14 men with lung cancer but no history of occupational dust exposure, and in a series of 14 control men matched for age, smoking history, and general occupational class. The lung cancer patients had an average of 525 +/- 369 X 10(6) exogenous mineral particles and 17.4 +/- 19.6 X 10(6) exogenous minera...

Fine particles and mortality.

In an interesting paper in a recent issue (vol 17, issue 14) of the journal, Enstrom examined the association between fine particulate matter (PM) pollution and mortality in a cohort of elderly Californians. The analyses used proportional hazards regression and after adjusting for age, sex, cigarette smoking, and other potential confounders, Enstrom concluded, “These epidemiologic results do no...

FINAL REPORT Effects of Inhaled Fine Particles on Lung Growth and Lung Disease